InnateDB Protein
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IDBP-155228.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Set
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Protein Name
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SET nuclear oncogene
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Synonyms
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2610030F17Rik; 5730420M11Rik; AA407739; I-2PP2A; StF-IT-1; TAF-I;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000070002
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InnateDB Gene
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IDBG-155224 (Set)
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Protein Structure
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Function |
Multitasking protein, involved in apoptosis, transcription, nucleosome assembly and histone chaperoning. Isoform 2 anti-apoptotic activity is mediated by inhibition of the GZMA-activated DNase, NME1. In the course of cytotoxic T- lymphocyte (CTL)-induced apoptosis, GZMA cleaves SET, disrupting its binding to NME1 and releasing NME1 inhibition. Isoform 1 and isoform 2 are potent inhibitors of protein phosphatase 2A. Isoform 1 and isoform 2 inhibit EP300/CREBBP and PCAF-mediated acetylation of histones (HAT) and nucleosomes, most probably by masking the accessibility of lysines of histones to the acetylases. The predominant target for inhibition is histone H4. HAT inhibition leads to silencing of HAT-dependent transcription and prevents active demethylation of DNA. Both isoforms stimulate DNA replication of the adenovirus genome complexed with viral core proteins; however, isoform 2 specific activity is higher (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=In the cytoplasm, found both in the cytosol and associated with the endoplasmic reticulum. The SET complex is associated with the endoplasmic reticulum. Following CTL attack and cleavage by GZMA, moves rapidly to the nucleus, where it is found in the nucleoplasm, avoiding the nucleolus. Similar translocation to the nucleus is also observed for lymphocyte- activated killer cells after the addition of calcium (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 89 interaction(s) predicted by orthology.
Experimentally validated |
Total |
51
[view]
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Protein-Protein |
51
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
89 [view]
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Molecular Function |
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Biological Process |
GO:0006334
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nucleosome assembly
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GO:0043524
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negative regulation of neuron apoptotic process
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GO:0045892
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negative regulation of transcription, DNA-templated
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Cellular Component |
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PDB ID |
MGI:1860267
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InterPro |
IPR002164
Nucleosome assembly protein (NAP)
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PFAM |
PF00956
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9EQU5
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PhosphoSite |
PhosphoSite-Q9EQU5
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56086
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UniGene |
Mm.472329
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RefSeq |
NP_001191804
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MGI ID |
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MGI Symbol |
Set
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OMIM |
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CCDS |
CCDS57162
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HPRD |
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IMGT |
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EMBL |
AB015613
AB044937
AK011630
AK019960
BC018255
BX005298
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GenPept |
AAH18255
BAA34736
BAB20793
BAB27745
BAB31936
CAM18951
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