InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Set

Summary

InnateDB Gene

IDBG-155224.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Set

Gene Name

SET nuclear oncogene

Synonyms

2610030F17Rik; 5730420M11Rik; AA407739; I-2PP2A; StF-IT-1; TAF-I

Species

Mus musculus

Ensembl Gene

ENSMUSG00000054766

Encoded Proteins

IDBP-155226

SET nuclear oncogene

IDBP-155228

SET nuclear oncogene

IDBP-534659

SET nuclear oncogene

IDBP-536679

SET nuclear oncogene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000119335:
The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:30057378-30072577

Strand

Forward strand

Band

Transcripts

ENSMUST00000102866	ENSMUSP00000099930
ENSMUST00000067996	ENSMUSP00000070002
ENSMUST00000134364	ENSMUSP00000114557
ENSMUST00000149578	ENSMUSP00000119824
ENSMUST00000125824
ENSMUST00000137291
ENSMUST00000147590

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.
They are also associated with 89 interaction(s) predicted by orthology.

Experimentally validated
Total	51 [view]
Protein-Protein	51 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	89 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding

Biological Process

GO:0006334	nucleosome assembly
GO:0043524	negative regulation of neuron apoptotic process
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm