InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Impa2

Summary

InnateDB Protein

IDBP-155264.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Impa2

Protein Name

inositol (myo)-1(or 4)-monophosphatase 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025403

InnateDB Gene

IDBG-155262 (Impa2)

Protein Structure

UniProt Annotation

Function

Can use myo-inositol monophosphates, scylloinositol 1,4- diphosphate, glucose-1-phosphate, beta-glycerophosphate, and 2'- AMP as substrates. Has been implicated as the pharmacological target for lithium Li(+) action in brain (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Mostly expressed in brain, small intestine, heart, kidney, and spleen (at protein level). {ECO:0000269PubMed:17068342}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008934	inositol monophosphate 1-phosphatase activity
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0052832	inositol monophosphate 3-phosphatase activity
GO:0052833	inositol monophosphate 4-phosphatase activity

Biological Process

GO:0006020	inositol metabolic process
GO:0006021	inositol biosynthetic process
GO:0046854	phosphatidylinositol phosphorylation
GO:0046855	inositol phosphate dephosphorylation