InnateDB Protein
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IDBP-155364.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Smyd1
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Protein Name
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SET and MYND domain containing 1
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Synonyms
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4632404M21Rik; Bop; C78565; Zmynd18;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000073911
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InnateDB Gene
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IDBG-155362 (Smyd1)
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Protein Structure
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Function |
Methylates histone H3 at 'Lys-4' (H3K4me). Acts as a transcriptional repressor. Essential for cardiomyocyte differentiation and cardiac morphogenesis. {ECO:0000269PubMed:11923873, ECO:0000269PubMed:20943667}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:11923873}. Nucleus {ECO:0000269PubMed:11923873}.
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Disease Associations |
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Tissue Specificity |
Expressed in cardiac and skeletal muscle, lymphocytes and thymus. {ECO:0000269PubMed:11923873, ECO:0000269PubMed:9013956}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:104790
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InterPro |
IPR001214
SET domain
IPR002893
Zinc finger, MYND-type
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PFAM |
PF00856
PF01753
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PRINTS |
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PIRSF |
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SMART |
SM00317
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TIGRFAMs |
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Modification |
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SwissProt |
P97443
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PhosphoSite |
PhosphoSite-P97443
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
12180
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UniGene |
Mm.440892
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RefSeq |
NP_001153599
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MGI ID |
3N71
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MGI Symbol |
Smyd1
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OMIM |
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CCDS |
CCDS51805
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HPRD |
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IMGT |
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EMBL |
AK142252
BC076601
CH466523
U76371
U76373
U76374
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GenPept |
AAC53020
AAC53021
AAC53022
AAH76601
BAE24995
EDK98934
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