InnateDB Protein
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IDBP-155469.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Usp2
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Protein Name
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ubiquitin specific peptidase 2
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Synonyms
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B930035K21Rik; Ubp41;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000034508
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InnateDB Gene
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IDBG-155467 (Usp2)
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Protein Structure
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Function |
Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 2 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:14686789}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Localizes in the spermatid head in late-elongating spermatids in the thin area between the outer acrosomal membrane and the plasma membrane. {ECO:0000250}.Isoform 2: Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Isoform 1 is expressed in heart, liver, kidney, pancreas and to a lower extent in skeletal muscle, brain and testis (at protein level). Expressed in testis, brain, heart and skeletal muscle. {ECO:0000269PubMed:14686789}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 63 interaction(s) predicted by orthology.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
63 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006511
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ubiquitin-dependent protein catabolic process
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GO:0007049
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cell cycle
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GO:0007517
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muscle organ development
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GO:0016579
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protein deubiquitination
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GO:0045931
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positive regulation of mitotic cell cycle
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GO:0048642
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negative regulation of skeletal muscle tissue development
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GO:0048643
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positive regulation of skeletal muscle tissue development
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GO:0050821
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protein stabilization
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Cellular Component |
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PDB ID |
MGI:1858178
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InterPro |
IPR001394
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
IPR028889
Ubiquitin carboxyl-terminal hydrolase-like domain
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PFAM |
PF00443
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O88623
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PhosphoSite |
PhosphoSite-O88623
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TrEMBL |
H3BLN9
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UniProt Splice Variant |
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Entrez Gene |
53376
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UniGene |
Mm.420660
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RefSeq |
NP_932760
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MGI ID |
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MGI Symbol |
Usp2
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OMIM |
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CCDS |
CCDS23094
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HPRD |
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IMGT |
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EMBL |
AB041799
AC148328
AF079565
AK138799
AY255637
AY255638
AY255639
AY255640
BC017517
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GenPept |
AAC28393
AAH17517
AAQ83301
AAQ83302
AAQ83303
AAQ83304
BAA95110
BAE23782
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