InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbxw7

Summary

InnateDB Protein

IDBP-155474.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxw7

Protein Name

F-box and WD-40 domain protein 7

Synonyms

1110001A17Rik; AGO; Cdc4; Fbw7; Fbwd6; Fbx30; Fbxo30; Fbxw6; SEL-10;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029727

InnateDB Gene

IDBG-155472 (Fbxw7)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000269PubMed:11461910}. Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in brain, heart and testis. {ECO:0000269PubMed:11735228}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	77 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0001570	vasculogenesis
GO:0006355	regulation of transcription, DNA-templated
GO:0007219	Notch signaling pathway
GO:0016567	protein ubiquitination
GO:0030324	lung development
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0019005	SCF ubiquitin ligase complex
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1354695

InterPro

IPR001680 WD40 repeat
IPR001810 F-box domain
IPR011044 Quinoprotein amine dehydrogenase, beta chain-like
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat

PFAM

PF00400
PF00646
PF12937
PF13013

PRINTS

PR00320

PIRSF

SMART

SM00320
SM00256

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt