InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Emd

Summary

InnateDB Protein

IDBP-155502.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Emd

Protein Name

emerin

Synonyms

AW550900; Sta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002029

InnateDB Gene

IDBG-155498 (Emd)

Protein Structure

UniProt Annotation

Function

Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta- catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus outer membrane. Note=Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non- farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in embryonic fibroblasts, skeletal muscle, heart muscle and tongue epithelium (at protein level). Widely expressed. {ECO:0000269PubMed:10579712, ECO:0000269PubMed:9107678}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	92 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0048487	beta-tubulin binding

Biological Process

GO:0035414	negative regulation of catenin import into nucleus
GO:0035914	skeletal muscle cell differentiation
GO:0046827	positive regulation of protein export from nucleus
GO:0048147	negative regulation of fibroblast proliferation
GO:0060828	regulation of canonical Wnt signaling pathway
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0005640	nuclear outer membrane
GO:0005652	nuclear lamina
GO:0005783	endoplasmic reticulum
GO:0005874	microtubule
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031965	nuclear membrane