Version 5.4
Mus musculus Protein: Cpsf1
Summary
InnateDB Protein IDBP-155864.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cpsf1
Protein Name cleavage and polyadenylation specific factor 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000071794
InnateDB Gene IDBG-155862 (Cpsf1)
Protein Structure
UniProt Annotation
Function Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre- mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus, nucleoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
Biological Process
GO:0006378 mRNA polyadenylation
GO:0006379 mRNA cleavage
Cellular Component
GO:0005634 nucleus
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
Protein Structure and Domains
PDB ID MGI:2679722
InterPro IPR004871 Cleavage/polyadenylation specificity factor, A subunit, C-terminal
PFAM PF03178
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9EPU4
PhosphoSite PhosphoSite-Q9EPU4
TrEMBL
UniProt Splice Variant
Entrez Gene 94230
UniGene Mm.45141
RefSeq NP_444423
MGI ID
MGI Symbol Cpsf1
OMIM
CCDS CCDS27577
HPRD
IMGT
EMBL AF322193 BC056388
GenPept AAG40326 AAH56388

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca