InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cpsf1

Summary

InnateDB Gene

IDBG-155862.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cpsf1

Gene Name

cleavage and polyadenylation specific factor 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000034022

Encoded Proteins

IDBP-155864

cleavage and polyadenylation specific factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000071894:
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009] Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]).[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:76595809-76607591

Strand

Reverse strand

Band

Transcripts

ENSMUST00000071898

ENSMUSP00000071794

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding

Biological Process

GO:0006378	mRNA polyadenylation
GO:0006379	mRNA cleavage

Cellular Component

GO:0005634	nucleus
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000071894

View Gene Order

ENSBTAG00000008355

Not yet available

Pathways

NETPATH

REACTOME

REACT_240247

mRNA 3'-end processing pathway

REACT_237682

Transport of Mature Transcript to Cytoplasm pathway

REACT_249110

mRNA Splicing pathway

REACT_248407

Processing of Capped Intronless Pre-mRNA pathway

REACT_232123

Processing of Intronless Pre-mRNAs pathway

REACT_257346

RNA Polymerase II Transcription Termination pathway

REACT_253727

Cleavage of Growing Transcript in the Termination Region pathway

REACT_233572

Gene Expression pathway

REACT_260226

mRNA Splicing - Major Pathway pathway

REACT_244199

Transport of Mature mRNA Derived from an Intronless Transcript pathway

REACT_250734

Transport of Mature mRNAs Derived from Intronless Transcripts pathway

REACT_233950

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_242255

RNA Polymerase II Transcription pathway

KEGG

mmu03015

mRNA surveillance pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_1096

Processing of Intronless Pre-mRNAs pathway

REACT_1849

mRNA 3'-end processing pathway

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_1835

Transport of Mature mRNA Derived from an Intronless Transcript pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_387

Cleavage of Growing Transcript in the Termination Region pathway

REACT_894

RNA Polymerase II Transcription Termination pathway

REACT_1366

RNA Polymerase II Transcription pathway

REACT_1281

Transport of Mature Transcript to Cytoplasm pathway

REACT_1768

Processing of Capped Intronless Pre-mRNA pathway

REACT_338

Transport of Mature mRNAs Derived from Intronless Transcripts pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

REACT_209718

RNA Polymerase II Transcription pathway

REACT_224643

Cleavage of Growing Transcript in the Termination Region pathway

REACT_205948

mRNA Splicing - Major Pathway pathway

REACT_206725

mRNA Splicing pathway

REACT_204974

Processing of Capped Intronless Pre-mRNA pathway

REACT_203211

mRNA 3'-end processing pathway

REACT_224602

Transport of Mature Transcript to Cytoplasm pathway

REACT_224606

RNA Polymerase II Transcription Termination pathway

REACT_207634

Transport of Mature mRNA Derived from an Intronless Transcript pathway

REACT_226022

Gene Expression pathway

REACT_226302

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_225642

Processing of Intronless Pre-mRNAs pathway

REACT_210287

Transport of Mature mRNAs Derived from Intronless Transcripts pathway

KEGG

hsa03015

mRNA surveillance pathway pathway

INOH

PID NCI

Cross-References

SwissProt

Q9EPU4

TrEMBL

UniProt Splice Variant

Entrez Gene

94230

UniGene

Mm.45141

RefSeq

NM_001164173 NM_053193 XM_006521600 XM_006521601 XM_006521602 XM_006521603

OMIM

CCDS

CCDS27577

HPRD

IMGT

MGI ID

MGI:2679722

MGI Symbol

Cpsf1

EMBL

AF322193 BC056388

GenPept

AAG40326 AAH56388

RNA Seq Atlas

94230