InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grk4

Summary

InnateDB Protein

IDBP-155872.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grk4

Protein Name

G protein-coupled receptor kinase 4

Synonyms

A830025H08Rik; Gprk2l; Gprk4; GRK;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001112

InnateDB Gene

IDBG-155868 (Grk4)

Protein Structure

UniProt Annotation

Function

Specifically phosphorylates the activated forms of G protein-coupled receptors.

Subcellular Localization

Cytoplasm. Cytoplasm, cell cortex {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004703	G-protein coupled receptor kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0050254	rhodopsin kinase activity

Biological Process

GO:0002029	desensitization of G-protein coupled receptor protein signaling pathway
GO:0002031	G-protein coupled receptor internalization
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0031623	receptor internalization
GO:0038032	termination of G-protein coupled receptor signaling pathway

Cellular Component

GO:0005829	cytosol
GO:0005938	cell cortex
GO:0030425	dendrite
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:95801

InterPro

IPR000239 GPCR kinase
IPR000342 Regulator of G protein signalling domain
IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR016137 Regulator of G protein signalling superfamily
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00615
PF00069
PF07714

PRINTS

PR00717
PR01301
PR00109

PIRSF

SMART

SM00133
SM00220
SM00315
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt