InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hpgd

Summary

InnateDB Protein

IDBP-155952.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hpgd

Protein Name

hydroxyprostaglandin dehydrogenase 15 (NAD)

Synonyms

15-PGDH; AV026552;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034026

InnateDB Gene

IDBG-155950 (Hpgd)

Protein Structure

UniProt Annotation

Function

Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in lung, intestine, stomach and liver. {ECO:0000269PubMed:8950170}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004957	prostaglandin E receptor activity
GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity
GO:0016491	oxidoreductase activity
GO:0050662	coenzyme binding
GO:0051287	NAD binding
GO:0070403	NAD+ binding

Biological Process

GO:0006693	prostaglandin metabolic process
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007565	female pregnancy
GO:0007567	parturition
GO:0008152	metabolic process
GO:0030728	ovulation
GO:0044237	cellular metabolic process
GO:0045786	negative regulation of cell cycle
GO:0055114	oxidation-reduction process
GO:0070493	thrombin receptor signaling pathway
GO:0097070	ductus arteriosus closure

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016323	basolateral plasma membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:108085

InterPro

IPR001509 NAD-dependent epimerase/dehydratase
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
IPR002424 Alcohol dehydrogenase, insect-type
IPR003560 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
IPR013968 Polyketide synthase, KR

PFAM

PF01370
PF00106
PF08659

PRINTS

PR00080
PR00081
PR01167
PR01397

PIRSF

PIRSF000126

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt