InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Hpgd

Summary

InnateDB Gene

IDBG-155950.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hpgd

Gene Name

hydroxyprostaglandin dehydrogenase 15 (NAD)

Synonyms

15-PGDH; AV026552

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031613

Encoded Proteins

IDBP-155952

hydroxyprostaglandin dehydrogenase 15 (NAD)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164120:
This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:56294552-56321046

Strand

Forward strand

Band

Transcripts

ENSMUST00000034026

ENSMUSP00000034026

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004957	prostaglandin E receptor activity
GO:0016404	15-hydroxyprostaglandin dehydrogenase (NAD+) activity
GO:0016491	oxidoreductase activity
GO:0050662	coenzyme binding
GO:0051287	NAD binding
GO:0070403	NAD+ binding

Biological Process

GO:0006693	prostaglandin metabolic process
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007565	female pregnancy
GO:0007567	parturition
GO:0008152	metabolic process
GO:0030728	ovulation
GO:0044237	cellular metabolic process
GO:0045786	negative regulation of cell cycle
GO:0055114	oxidation-reduction process
GO:0070493	thrombin receptor signaling pathway
GO:0097070	ductus arteriosus closure