InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Plxna3

Summary

InnateDB Protein

IDBP-156041.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Plxna3

Protein Name

plexin A3

Synonyms

mKIAA4078; PlexA3; Plxa3; Plxn3; Plxn4; SEX;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000004326

InnateDB Gene

IDBG-156039 (Plxna3)

Protein Structure

UniProt Annotation

Function

Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. {ECO:0000269PubMed:11683995, ECO:0000269PubMed:18262512, ECO:0000269PubMed:18804103, ECO:0000269PubMed:19020035, ECO:0000269PubMed:19717441, ECO:0000269PubMed:20010807}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Detected in embryonic hindbrain, spinal cord, dorsal root ganglion, trigeminal ganglion and superior cervical ganglion. In newborns, detected throughout all layers of the hippocampus. {ECO:0000269PubMed:11683995, ECO:0000269PubMed:18804103, ECO:0000269PubMed:8806646}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0017154	semaphorin receptor activity

Biological Process

GO:0007165	signal transduction
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0021612	facial nerve structural organization
GO:0021637	trigeminal nerve structural organization
GO:0021766	hippocampus development
GO:0021785	branchiomotor neuron axon guidance
GO:0021860	pyramidal neuron development
GO:0048843	negative regulation of axon extension involved in axon guidance
GO:0050919	negative chemotaxis
GO:0051495	positive regulation of cytoskeleton organization
GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:107683

InterPro

IPR001627 Sema domain
IPR002165 Plexin
IPR002909 IPT domain
IPR008936 Rho GTPase activation protein
IPR013548 Plexin, cytoplasmic RasGAP domain
IPR014756 Immunoglobulin E-set
IPR016201 Plexin-like fold

PFAM

PF01403
PF01437
PF01833
PF08337

PRINTS

PIRSF

SMART

SM00630
SM00429
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70208