InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbxo8

Summary

InnateDB Protein

IDBP-156107.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxo8

Protein Name

F-box protein 8

Synonyms

Fbx8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037544

InnateDB Gene

IDBG-156105 (Fbxo8)

Protein Structure

UniProt Annotation

Function

May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential). {ECO:0000305}.

Subcellular Localization

Disease Associations

Tissue Specificity

High expression in brain, heart, kidney, liver, lung, skeletal muscle, testis, and day-7 embryos.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005086	ARF guanyl-nucleotide exchange factor activity
GO:0005515	protein binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0030036	actin cytoskeleton organization
GO:0032012	regulation of ARF protein signal transduction
GO:0043087	regulation of GTPase activity