Version 5.4
Mus musculus Gene: Fbxo8
Summary
InnateDB Gene IDBG-156105.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fbxo8
Gene Name F-box protein 8
Synonyms Fbx8
Species Mus musculus
Ensembl Gene ENSMUSG00000038206
Encoded Proteins
IDBP-156107
F-box protein 8
IDBP-260519
F-box protein 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164117:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide exchange factor) activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:56551090-56592393
Strand Forward strand
Band B2
Transcripts
ENSMUST00000040218 ENSMUSP00000037544
ENSMUST00000110322 ENSMUSP00000105951
ENSMUST00000156840
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005086 ARF guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0030036 actin cytoskeleton organization
GO:0032012 regulation of ARF protein signal transduction
GO:0043087 regulation of GTPase activity
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005634 nucleus
GO:0030054 cell junction
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164117
View Gene Order
ENSBTAG00000006715
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
arf6_pathway
Arf6 signaling events
Cross-References
SwissProt
TrEMBL Q921R9
UniProt Splice Variant
Entrez Gene 50753
UniGene Mm.251174 Mm.398860
RefSeq NM_015791
OMIM
CCDS CCDS22314
HPRD
IMGT
MGI ID MGI:1354696
MGI Symbol Fbxo8
EMBL AC116121 BC011100 CH466569
GenPept AAH11100 EDL28607
RNA Seq Atlas 50753

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca