InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tysnd1

Summary

InnateDB Protein

IDBP-156234.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tysnd1

Protein Name

trypsin domain containing 1

Synonyms

1300019N10Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020284

InnateDB Gene

IDBG-156232 (Tysnd1)

Protein Structure

UniProt Annotation

Function

Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta- oxidation of fatty acids (By similarity). {ECO:0000250}.

Subcellular Localization

Peroxisome {ECO:0000269PubMed:17255948}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0003824	catalytic activity
GO:0004252	serine-type endopeptidase activity
GO:0042802	identical protein binding

Biological Process

GO:0006508	proteolysis
GO:0016485	protein processing
GO:0031998	regulation of fatty acid beta-oxidation
GO:0051260	protein homooligomerization

Cellular Component

GO:0005777	peroxisome
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1919017

InterPro

IPR001254 Peptidase S1
IPR009003 Trypsin-like cysteine/serine peptidase domain
IPR017345 Peptidase S1A, Tysnd1

PFAM

PF00089

PRINTS

PIRSF

PIRSF037989

SMART

SM00020

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

MGI ID

MGI Symbol

OMIM

CCDS

HPRD

IMGT

EMBL

AK005069 AK154513 BC119320

GenPept

AAI19321 BAB23793 BAE32642

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1)

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca