Version 5.4
Mus musculus Protein: Dok3
Summary
InnateDB Protein IDBP-156243.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dok3
Protein Name docking protein 3
Synonyms AI450713; Dokl;
Species Mus musculus
Ensembl Protein ENSMUSP00000046695
InnateDB Gene IDBG-156241 (Dok3)
Protein Structure
UniProt Annotation
Function DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function. {ECO:0000269PubMed:14993273}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Disease Associations
Tissue Specificity Predominantly expressed in bone marrow, spleen and lung. Low levels in heart, brain, liver, muscle, thymus, kidney and testis. Highly expressed in B-cells and macrophages. {ECO:0000269PubMed:10567556, ECO:0000269PubMed:10733577}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
GO:0007265 Ras protein signal transduction
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:1351490
InterPro IPR001849 Pleckstrin homology domain
IPR002404 Insulin receptor substrate-1, PTB
PFAM PF00169
PF02174
PRINTS PR00628
PIRSF
SMART SM00233
SM00310
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QZK7
PhosphoSite PhosphoSite-Q9QZK7
TrEMBL Q14AA1
UniProt Splice Variant
Entrez Gene 27261
UniGene Mm.33910
RefSeq NP_038767
MGI ID
MGI Symbol Dok3
OMIM
CCDS CCDS26548
HPRD
IMGT
EMBL AF179242 AF237580 BC116922 BC120535 CH466546
GenPept AAF14285 AAF61309 AAI16923 AAI20536 EDL41210

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca