Version 5.4
Mus musculus Gene: Dok3
Summary
InnateDB Gene IDBG-156241.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dok3
Gene Name docking protein 3
Synonyms AI450713; Dokl
Species Mus musculus
Ensembl Gene ENSMUSG00000035711
Encoded Proteins
IDBP-156243
docking protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22761938
Dok3 is a negative regulator of TLR signalling by limiting LPS-induced ERK activation and cytokine responses in macrophages.
InnateDB Annotation from Orthologs
Summary
PMID 22761938
[Homo sapiens] DOK3 is a negative regulator of TLR signalling by limiting LPS-induced ERK activation and cytokine responses in macrophages. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146094:
Gene Information
Type Protein coding
Genomic Location Chromosome 13:55523235-55528538
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000047877 ENSMUSP00000046695
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
GO:0007265 Ras protein signal transduction
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000146094
View Gene Order
ENSBTAG00000025401
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_6
KitReceptor pathway
NetPath_12
BCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.33910
RefSeq NM_013739
OMIM
CCDS CCDS26548
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca