InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: H2afy2

Summary

InnateDB Protein

IDBP-156385.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

H2afy2

Protein Name

H2A histone family, member Y2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020283

InnateDB Gene

IDBG-156383 (H2afy2)

Protein Structure

UniProt Annotation

Function

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.

Subcellular Localization

Nucleus {ECO:0000269PubMed:11262398}. Chromosome {ECO:0000269PubMed:11262398}. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.

Disease Associations

Tissue Specificity

Present in liver, kidney and adrenal gland (at protein level). In the liver, present in cells of the bile ducts and parenchymal cells, but not in hepatocytes. In the kidney, present in proximal and distal convoluted tubules and in glomeruli. Present at highest levels in the parietal layer of Bowman capsule. In the adrenal gland, present in the outer cells of the capsule. {ECO:0000269PubMed:11262398}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0031490	chromatin DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006334	nucleosome assembly
GO:0007420	brain development
GO:0007549	dosage compensation
GO:0016568	chromatin modification
GO:0045814	negative regulation of gene expression, epigenetic
GO:0071169	establishment of protein localization to chromatin
GO:1901837	negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter

Cellular Component

GO:0000786	nucleosome
GO:0000790	nuclear chromatin
GO:0001740	Barr body
GO:0005634	nucleus
GO:0035098	ESC/E(Z) complex
GO:0070062	extracellular vesicular exosome