InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cd1d1

Summary

InnateDB Protein

IDBP-156737.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cd1d1

Protein Name

CD1d1 antigen

Synonyms

AI747460; CD1.1; Cd1a; Cd1d; Ly-38;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029717

InnateDB Gene

IDBG-156735 (Cd1d1)

Protein Structure

UniProt Annotation

Function

Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269PubMed:11754812, ECO:0000269PubMed:16007091, ECO:0000269PubMed:16314439}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:11754812}; Single-pass type I membrane protein {ECO:0000269PubMed:11754812}. Endosome membrane {ECO:0000269PubMed:11754812}. Lysosome membrane {ECO:0000269PubMed:11754812}. Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes.

Disease Associations

Tissue Specificity

Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	2 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0030881	beta-2-microglobulin binding
GO:0030883	endogenous lipid antigen binding
GO:0030884	exogenous lipid antigen binding
GO:0042608	T cell receptor binding
GO:0071723	lipopeptide binding

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0019882	antigen processing and presentation
GO:0043032	positive regulation of macrophage activation
GO:0045059	positive thymic T cell selection
GO:0045078	positive regulation of interferon-gamma biosynthetic process
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response
GO:0045404	positive regulation of interleukin-4 biosynthetic process
GO:0048007	antigen processing and presentation, exogenous lipid antigen via MHC class Ib
GO:0050776	regulation of immune response
GO:0051135	positive regulation of NK T cell activation
GO:0051138	positive regulation of NK T cell differentiation

Cellular Component

GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0005769	early endosome
GO:0005770	late endosome
GO:0009897	external side of plasma membrane
GO:0010008	endosome membrane
GO:0016021	integral component of membrane