Version 5.4
Mus musculus Gene: Cd1d1
Summary
InnateDB Gene IDBG-156735.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cd1d1
Gene Name CD1d1 antigen
Synonyms AI747460; CD1.1; Cd1a; Cd1d; Ly-38
Species Mus musculus
Ensembl Gene ENSMUSG00000028076
Encoded Proteins
IDBP-156737
CD1d1 antigen
IDBP-156739
CD1d1 antigen
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 24248359
[Homo sapiens] Lipid transfer proteins saposins play an essential role in modulating human invariant natural killer T cell reactivity to antigen-presenting cells activated by inflammatory stimuli. Lipid-loaded Saposin B mediates lipid transfer onto CD1D and accelerates dissociation of CD1D-bound lipids, promoting lipid exchange.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158473:
This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:86995834-86999441
Strand Reverse strand
Band F1
Transcripts
ENSMUST00000029717 ENSMUSP00000029717
ENSMUST00000063869 ENSMUSP00000070616
ENSMUST00000107620
ENSMUST00000132131
ENSMUST00000142793
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 2 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0030881 beta-2-microglobulin binding
GO:0030883 endogenous lipid antigen binding
GO:0030884 exogenous lipid antigen binding
GO:0042608 T cell receptor binding
GO:0071723 lipopeptide binding
Biological Process
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0006955 immune response
GO:0019882 antigen processing and presentation
GO:0043032 positive regulation of macrophage activation
GO:0045059 positive thymic T cell selection
GO:0045078 positive regulation of interferon-gamma biosynthetic process
GO:0045086 positive regulation of interleukin-2 biosynthetic process
GO:0045087 innate immune response
GO:0045404 positive regulation of interleukin-4 biosynthetic process
GO:0048007 antigen processing and presentation, exogenous lipid antigen via MHC class Ib
GO:0050776 regulation of immune response
GO:0051135 positive regulation of NK T cell activation
GO:0051138 positive regulation of NK T cell differentiation
Cellular Component
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005769 early endosome
GO:0005770 late endosome
GO:0009897 external side of plasma membrane
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000158473
View Gene Order
Pathways
NETPATH
REACTOME
KEGG
mmu04640
Hematopoietic cell lineage pathway
mmu05146
Amoebiasis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04640
Hematopoietic cell lineage pathway
hsa05146
Amoebiasis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.1894
RefSeq NM_007639
OMIM
CCDS CCDS17449
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca