InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ak3

Summary

InnateDB Protein

IDBP-156791.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ak3

Protein Name

adenylate kinase 3

Synonyms

AA407498; AI506714; AK-3; Ak3l; Ak3l1; Akl3l;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025696

InnateDB Gene

IDBG-156789 (Ak3)

Protein Structure

UniProt Annotation

Function

Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. {ECO:0000255HAMAP-Rule:MF_03169}.

Subcellular Localization

Mitochondrion matrix {ECO:0000255HAMAP- Rule:MF_03169}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004017	adenylate kinase activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0016776	phosphotransferase activity, phosphate group as acceptor
GO:0046899	nucleoside triphosphate adenylate kinase activity

Biological Process

GO:0046033	AMP metabolic process
GO:0046039	GTP metabolic process
GO:0046041	ITP metabolic process
GO:0046051	UTP metabolic process
GO:0046939	nucleotide phosphorylation

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Protein Structure and Domains

PDB ID

MGI:1860835

InterPro

IPR000850 Adenylate kinase/UMP-CMP kinase
IPR006259 Adenylate kinase subfamily
IPR007862 Adenylate kinase, active site lid domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF05191

PRINTS

PR00094

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9WTP7