InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Neurog3

Summary

InnateDB Protein

IDBP-156911.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Neurog3

Protein Name

neurogenin 3

Synonyms

Atoh5; bHLHa7; Math4B; ngn3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000054054

InnateDB Gene

IDBG-156909 (Neurog3)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional regulator. Together with NKX2- 2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types. {ECO:0000269PubMed:10677506, ECO:0000269PubMed:19759004}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00981}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001047	core promoter binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0031490	chromatin DNA binding
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0021510	spinal cord development
GO:0030855	epithelial cell differentiation
GO:0030900	forebrain development
GO:0030902	hindbrain development
GO:0031018	endocrine pancreas development
GO:0045597	positive regulation of cell differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048814	regulation of dendrite morphogenesis
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060290	transdifferentiation