Version 5.4
Mus musculus Gene: Neurog3
Summary
InnateDB Gene IDBG-156909.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Neurog3
Gene Name neurogenin 3
Synonyms Atoh5; bHLHa7; Math4B; ngn3
Species Mus musculus
Ensembl Gene ENSMUSG00000044312
Encoded Proteins
IDBP-156911
neurogenin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122859:
The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Defects in this gene are a cause of congenital malabsorptive diarrhea 4 (DIAR4).[provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:62133090-62134763
Strand Forward strand
Band B4
Transcripts
ENSMUST00000050103 ENSMUSP00000054054
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001047 core promoter binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003690 double-stranded DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0031490 chromatin DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organismal development
GO:0021510 spinal cord development
GO:0030855 epithelial cell differentiation
GO:0030900 forebrain development
GO:0030902 hindbrain development
GO:0031018 endocrine pancreas development
GO:0045597 positive regulation of cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048814 regulation of dendrite morphogenesis
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060290 transdifferentiation
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000122859
View Gene Order
ENSBTAG00000006431
Not yet available
Pathways
NETPATH
REACTOME
REACT_222486
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells pathway
REACT_221082
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells pathway
REACT_188576
Developmental Biology pathway
REACT_205507
Regulation of beta-cell development pathway
KEGG
mmu04950
Maturity onset diabetes of the young pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_13650
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells pathway
REACT_13673
Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells pathway
REACT_111045
Developmental Biology pathway
REACT_13698
Regulation of beta-cell development pathway
KEGG
hsa04950
Maturity onset diabetes of the young pathway
INOH
PID NCI
hes_heypathway
Notch-mediated HES/HEY network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.57236
RefSeq NM_009719
OMIM
CCDS CCDS23887
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca