InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pitx1

Summary

InnateDB Protein

IDBP-156934.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pitx1

Protein Name

paired-like homeodomain transcription factor 1

Synonyms

Bft; P-OTX; Potx; Ptx1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021968

InnateDB Gene

IDBG-156932 (Pitx1)

Protein Structure

UniProt Annotation

Function

May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Acts as a transcriptional activator by binding to promoter sequences with a TAAT/GCC core motif. Can independently activate and synergize with PIT-1 on pituitary-specific target gene promoters, thus may subserve functions in generating both precursor and specific cell phenotypes in the anterior pituitary gland and in several other organs. Can activate pituitary transcription of the proopiomelanocortin gene.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in primordial Rathke pouch, oral epithelium, first branchial arch, duodenum, and hindlimb.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001190	RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001501	skeletal system development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0014707	branchiomeric skeletal muscle development
GO:0021983	pituitary gland development
GO:0035116	embryonic hindlimb morphogenesis
GO:0035137	hindlimb morphogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048625	myoblast fate commitment
GO:0051216	cartilage development