Version 5.4
Mus musculus Gene: Pitx1
Summary
InnateDB Gene IDBG-156932.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pitx1
Gene Name paired-like homeodomain transcription factor 1
Synonyms Bft; P-OTX; Potx; Ptx1
Species Mus musculus
Ensembl Gene ENSMUSG00000021506
Encoded Proteins
IDBP-156934
paired-like homeodomain transcription factor 1
IDBP-622810
paired-like homeodomain transcription factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000069011:
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:55825051-55836192
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000021968 ENSMUSP00000021968
ENSMUST00000173618 ENSMUSP00000134609
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001190 RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0001501 skeletal system development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0014707 branchiomeric skeletal muscle development
GO:0021983 pituitary gland development
GO:0035116 embryonic hindlimb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048625 myoblast fate commitment
GO:0051216 cartilage development
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005730 nucleolus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000069011
View Gene Order
ENSBTAG00000004602
Not yet available
Cross-References
SwissProt
TrEMBL G3UZS0
UniProt Splice Variant
Entrez Gene 18740
UniGene Mm.135195
RefSeq NM_011097 XM_006517157 XM_006517158
OMIM
CCDS CCDS26556
HPRD
IMGT
MGI ID MGI:107374
MGI Symbol Pitx1
EMBL AC129780
GenPept
RNA Seq Atlas 18740

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca