Mus musculus Protein: H2afy | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-156986.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | H2afy | ||||||||||||||||||||||
Protein Name | H2A histone family, member Y | ||||||||||||||||||||||
Synonyms | H2AF12M; macroH2A1; mH2a1; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000038221 | ||||||||||||||||||||||
InnateDB Gene | IDBG-156982 (H2afy) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post- translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP- ribose, and may be involved in ADP-ribose-mediated chromatin modulation. {ECO:0000269PubMed:16107708}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus. Chromosome. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin. In quiescent lymphocytes, associated with centromeric constitutive heterochromatin. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Ubiquitously expressed, with high levels in testis. Present in liver, kidney and adrenal gland (at protein level). In the liver, present in hepatocytes and at a lesser extent in cells of the bile ducts. In the kidney, present in proximal and distal convoluted tubules and in straight proximal tubules. In the adrenal gland, present in inner cells of the cortex and medulla. {ECO:0000269PubMed:10471737, ECO:0000269PubMed:11262398}. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:1349392 | ||||||||||||||||||||||
InterPro |
IPR002119
Histone H2A IPR002589 Macro domain IPR007125 Histone core IPR009072 Histone-fold IPR021171 Core histone macro-H2A |
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PFAM |
PF01661
PF00125 |
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PRINTS |
PR00620
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PIRSF |
PIRSF037942
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SMART |
SM00414
SM00506 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | Q9QZQ8 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-Q9QZQ8 | ||||||||||||||||||||||
TrEMBL | Q9CTH9 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 26914 | ||||||||||||||||||||||
UniGene | Mm.490262 | ||||||||||||||||||||||
RefSeq | NP_001152987 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | H2afy | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS49278 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AB071988 AF171080 AF171081 AK003531 BC006955 | ||||||||||||||||||||||
GenPept | AAD53745 AAD53746 AAH06955 BAB22841 BAB68541 | ||||||||||||||||||||||