InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptges

Summary

InnateDB Protein

IDBP-157036.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptges

Protein Name

prostaglandin E synthase

Synonyms

2410099E23Rik; D2Ertd369e; mPGES; mPGES-1; Pges;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099916

InnateDB Gene

IDBG-157032 (Ptges)

Protein Structure

UniProt Annotation

Function

Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004667	prostaglandin-D synthase activity
GO:0043295	glutathione binding
GO:0050220	prostaglandin-E synthase activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0002526	acute inflammatory response
GO:0002544	chronic inflammatory response
GO:0006693	prostaglandin metabolic process
GO:0008285	negative regulation of cell proliferation
GO:0014070	response to organic cyclic compound
GO:0032496	response to lipopolysaccharide
GO:0032526	response to retinoic acid
GO:0034097	response to cytokine
GO:0045087	innate immune response (InnateDB)
GO:0051592	response to calcium ion

Cellular Component

GO:0005641	nuclear envelope lumen
GO:0005737	cytoplasm
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm