InnateDB Protein
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IDBP-157231.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mbd2
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Protein Name
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methyl-CpG binding domain protein 2
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Synonyms
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MBD2a;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000073701
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InnateDB Gene
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IDBG-157229 (Mbd2)
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Protein Structure
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Function |
Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (By similarity). May enhance the activation of some unmethylated cAMP-responsive promoters (By similarity). Selectively represses transcription activity of methylated rRNA promoters. {ECO:0000250, ECO:0000269PubMed:14610093, ECO:0000269PubMed:9774669}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in brain, heart, kidney, lung, skeletal muscle, spleen and testis. Detected at lower levels in embryonic stem cells. {ECO:0000269PubMed:9774669}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
27 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1333813
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InterPro |
IPR001739
Methyl-CpG DNA binding
IPR016177
DNA-binding domain
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PFAM |
PF01429
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PRINTS |
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PIRSF |
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SMART |
SM00391
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TIGRFAMs |
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Modification |
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SwissProt |
Q9Z2E1
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PhosphoSite |
PhosphoSite-Q9Z2E1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
17191
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UniGene |
Mm.472126
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RefSeq |
NP_034903
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MGI ID |
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MGI Symbol |
Mbd2
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OMIM |
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CCDS |
CCDS29335
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HPRD |
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IMGT |
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EMBL |
AC134831
AC166815
AC170591
AF072243
AF072245
AF120983
AF120984
AF120985
AF120986
BC046607
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GenPept |
AAC68872
AAC68874
AAD50372
AAD50373
AAH46607
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