InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mbd2

Summary

InnateDB Gene

IDBG-157229.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mbd2

Gene Name

methyl-CpG binding domain protein 2

Synonyms

MBD2a

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024513

Encoded Proteins

IDBP-157231

methyl-CpG binding domain protein 2

IDBP-250694

methyl-CpG binding domain protein 2

IDBP-541258

methyl-CpG binding domain protein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000134046:
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:70568189-70626131

Strand

Forward strand

Band

Transcripts

ENSMUST00000074058	ENSMUSP00000073701
ENSMUST00000114946	ENSMUSP00000110596
ENSMUST00000127260	ENSMUSP00000120508
ENSMUST00000133889
ENSMUST00000128555

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	12 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0008327	methyl-CpG binding
GO:0019904	protein domain specific binding
GO:0031492	nucleosomal DNA binding
GO:0035197	siRNA binding
GO:0070742	C2H2 zinc finger domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0030177	positive regulation of Wnt signaling pathway
GO:0042127	regulation of cell proliferation
GO:0042711	maternal behavior
GO:0043044	ATP-dependent chromatin remodeling
GO:0043623	cellular protein complex assembly

Cellular Component

GO:0000118	histone deacetylase complex
GO:0000785	chromatin
GO:0000790	nuclear chromatin
GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0043234	protein complex