Version 5.4
Mus musculus Protein: Pafah1b3
Summary
InnateDB Protein IDBP-157257.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pafah1b3
Protein Name platelet-activating factor acetylhydrolase, isoform 1b, subunit 3
Synonyms mus[g]; Pafahg;
Species Mus musculus
Ensembl Protein ENSMUSP00000005583
InnateDB Gene IDBG-157255 (Pafah1b3)
Protein Structure
UniProt Annotation
Function Inactivates paf by removing the acetyl group at the sn-2 position. This is a catalytic subunit. Plays an important role during the development of brain.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0005515 protein binding
GO:0016787 hydrolase activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0007283 spermatogenesis
GO:0007420 brain development
GO:0008152 metabolic process
GO:0016042 lipid catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:108414
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61205
PhosphoSite PhosphoSite-
TrEMBL Q3TJC2
UniProt Splice Variant
Entrez Gene 18476
UniGene Mm.597
RefSeq NP_032802
MGI ID
MGI Symbol Pafah1b3
OMIM
CCDS CCDS20979
HPRD
IMGT
EMBL AC156992 AK154547 AK167496 BC067015 CH466593 U57746
GenPept AAC52996 AAH67015 BAE32671 BAE39573 EDL24278

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca