InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cflar

Summary

InnateDB Protein

IDBP-157346.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cflar

Protein Name

CASP8 and FADD-like apoptosis regulator

Synonyms

2310024N18Rik; A430105C05Rik; c-Flip; Cash; Casper; CLARP; ENSMUSG00000072980; FLAME; FLAME-1; Flip; Gm9845; I-FLICE; MRIT;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095329

InnateDB Gene

IDBG-157342 (Cflar)

Protein Structure

UniProt Annotation

Function

Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Highly expressed in heart.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	8 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0007519	skeletal muscle tissue development
GO:0014732	skeletal muscle atrophy
GO:0014842	regulation of satellite cell proliferation
GO:0014866	skeletal myofibril assembly
GO:0042981	regulation of apoptotic process
GO:0043403	skeletal muscle tissue regeneration
GO:0045087	innate immune response (InnateDB)
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:1901740	negative regulation of myoblast fusion

Cellular Component

Protein Structure and Domains

PDB ID

MGI:1336166

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR001875 Death effector domain
IPR011029 Death-like domain
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core

PFAM

PF01335
PF00656

PRINTS

PR00376

PIRSF

SMART

SM00031
SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O35732

PhosphoSite

PhosphoSite-O35732

TrEMBL

UniProt Splice Variant

Entrez Gene

12633

UniGene

Mm.336848

RefSeq

MGI ID

MGI Symbol

Cflar

OMIM

CCDS

HPRD

IMGT

EMBL

AC112968 U97076 Y14041 Y14042

GenPept

AAC53281 CAA74368 CAA74369