InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cflar

Summary

InnateDB Gene

IDBG-157342.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cflar

Gene Name

CASP8 and FADD-like apoptosis regulator

Synonyms

2310024N18Rik; A430105C05Rik; c-Flip; Cash; Casper; CLARP; ENSMUSG00000072980; FLAME; FLAME-1; Flip; Gm9845; I-FLICE; MRIT

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026031

Encoded Proteins

IDBP-157346

CASP8 and FADD-like apoptosis regulator

IDBP-157348

CASP8 and FADD-like apoptosis regulator

IDBP-252044

CASP8 and FADD-like apoptosis regulator

IDBP-252046

CASP8 and FADD-like apoptosis regulator

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21635783

Cflar confers protection against cytoplasmic dsRNA-mediated cell death and down-regulates Irf3- and NFkB-mediated gene expression. In addition, Cflar also negatively regulates LPS-induced Tlr4-signalling in endothelial cells and protects against Tlr4-mediated apoptosis.

InnateDB Annotation from Orthologs

Summary

PMID 21635783

[Homo sapiens] CFLAR confers protection against cytoplasmic dsRNA-mediated cell death and down-regulates IRF3- and NFkB-mediated gene expression. In addition, CFLAR also negatively regulates LPS-induced TLR4-signalling in endothelial cells and protects against TLR4-mediated apoptosis. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000003402:
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:58711508-58758884

Strand

Forward strand

Band

C1.3

Transcripts

ENSMUST00000097723
ENSMUST00000097722	ENSMUSP00000095329
ENSMUST00000069333	ENSMUSP00000065107
ENSMUST00000114313	ENSMUSP00000109952
ENSMUST00000114309	ENSMUSP00000109948
ENSMUST00000140940
ENSMUST00000149874
ENSMUST00000156870
ENSMUST00000124567
ENSMUST00000123553
ENSMUST00000123032
ENSMUST00000164900
ENSMUST00000189858

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 55 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	8 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	55 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0007519	skeletal muscle tissue development
GO:0014732	skeletal muscle atrophy
GO:0014842	regulation of satellite cell proliferation
GO:0014866	skeletal myofibril assembly
GO:0042981	regulation of apoptotic process
GO:0043403	skeletal muscle tissue regeneration
GO:0045087	innate immune response (InnateDB)
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:1901740	negative regulation of myoblast fusion