InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tgfbi

Summary

InnateDB Protein

IDBP-157428.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tgfbi

Protein Name

transforming growth factor, beta induced

Synonyms

68kDa; AI181842; AI747162; Beta-ig; big-h3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037719

InnateDB Gene

IDBG-157426 (Tgfbi)

Protein Structure

UniProt Annotation

Function

Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=May be associated both with microfibrils and with the cell surface. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0050840	extracellular matrix binding

Biological Process

GO:0001525	angiogenesis
GO:0002062	chondrocyte differentiation
GO:0007155	cell adhesion
GO:0030198	extracellular matrix organization

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0005615	extracellular space
GO:0005802	trans-Golgi network
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome