InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mtif2

Summary

InnateDB Protein

IDBP-157484.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mtif2

Protein Name

mitochondrial translational initiation factor 2

Synonyms

2310038D14Rik; 2410112O06Rik; IF-2(Mt); IF-2mt; IF2(mt);

Species

Mus musculus

Ensembl Protein

ENSMUSP00000090926

InnateDB Gene

IDBG-157478 (Mtif2)

Protein Structure

UniProt Annotation

Function

One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003743	translation initiation factor activity
GO:0003924	GTPase activity
GO:0005525	GTP binding
GO:0008135	translation factor activity, nucleic acid binding
GO:0043024	ribosomal small subunit binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001732	formation of translation initiation complex
GO:0006184	GTP catabolic process
GO:0006446	regulation of translational initiation
GO:0007264	small GTPase mediated signal transduction
GO:0008150	biological_process
GO:0032790	ribosome disassembly

Cellular Component

GO:0005622	intracellular
GO:0005739	mitochondrion

Protein Structure and Domains

PDB ID

MGI:1924034

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR004161 Translation elongation factor EFTu/EF1A, domain 2
IPR005225 Small GTP-binding protein domain
IPR006073 GTP binding domain
IPR009000 Translation protein, beta-barrel domain
IPR013684 Mitochondrial Rho-like
IPR019009 Signal recognition particle receptor, beta subunit
IPR023115 Translation initiation factor IF- 2, domain 3
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF03144
PF01926
PF08477
PF09439
PF11987

PRINTS

PR00315
PR00326

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91YJ5