InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rbfox2

Summary

InnateDB Protein

IDBP-157580.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rbfox2

Protein Name

RNA binding protein, fox-1 homolog (C. elegans) 2

Synonyms

Fbm2; Fxh; Hrnbp2; Rbm9;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048056

InnateDB Gene

IDBG-157578 (Rbfox2)

Protein Structure

UniProt Annotation

Function

RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Prevents binding of U2AF2 to the 3'-splice site. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis. Seems to act as a coregulatory factor of ER-alpha (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm.

Disease Associations

Tissue Specificity

Detected in brain neurons (at protein level). Detected in heart, brain, embryo, lung, liver, kidney and ovary. {ECO:0000269PubMed:11401487, ECO:0000269PubMed:16260614}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003714	transcription corepressor activity
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding

Biological Process

GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010724	regulation of definitive erythrocyte differentiation
GO:0021942	radial glia guided migration of Purkinje cell
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0043484	regulation of RNA splicing
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048813	dendrite morphogenesis
GO:0050885	neuromuscular process controlling balance