InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kpna1

Summary

InnateDB Protein

IDBP-157605.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kpna1

Protein Name

karyopherin (importin) alpha 1

Synonyms

AW494490; IPOA5; mSRP1; NPI1; Rch2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000004054

InnateDB Gene

IDBG-157603 (Kpna1)

Protein Structure

UniProt Annotation

Function

Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Slightly detected in brain but not in cerebellum and skeletal muscle, highly expressed in testis and spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.