InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Stradb

Summary

InnateDB Protein

IDBP-157652.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stradb

Protein Name

STE20-related kinase adaptor beta

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027185

InnateDB Gene

IDBG-157650 (Stradb)

Protein Structure

UniProt Annotation

Function

Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000902	cell morphogenesis
GO:0006468	protein phosphorylation
GO:0006611	protein export from nucleus
GO:0007010	cytoskeleton organization
GO:0007049	cell cycle
GO:0007254	JNK cascade
GO:0032147	activation of protein kinase activity
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:2144047

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt