InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Stradb

Summary

InnateDB Gene

IDBG-157650.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stradb

Gene Name

STE20-related kinase adaptor beta

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026027

Encoded Proteins

IDBP-157652

STE20-related kinase adaptor beta

IDBP-252062

STE20-related kinase adaptor beta

IDBP-714771

IDBP-714397

IDBP-715439

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000082146:
This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:58973522-58995715

Strand

Forward strand

Band

C1.3

Transcripts

ENSMUST00000027185	ENSMUSP00000027185
ENSMUST00000114296	ENSMUSP00000109935
ENSMUST00000123301	ENSMUSP00000138036
ENSMUST00000153990	ENSMUSP00000137724
ENSMUST00000147637
ENSMUST00000123965
ENSMUST00000152318	ENSMUSP00000137790

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000902	cell morphogenesis
GO:0006468	protein phosphorylation
GO:0006611	protein export from nucleus
GO:0007010	cytoskeleton organization
GO:0007049	cell cycle
GO:0007254	JNK cascade
GO:0032147	activation of protein kinase activity
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand