InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddx60

Summary

InnateDB Protein

IDBP-157675.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Ddx60

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 60

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000091197

InnateDB Gene

IDBG-157673 (Ddx60)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003690	double-stranded DNA binding
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0003727	single-stranded RNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding

Biological Process

GO:0008152	metabolic process
GO:0009615	response to virus
GO:0051607	defense response to virus
GO:1900245	positive regulation of MDA-5 signaling pathway
GO:1900246	positive regulation of RIG-I signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0045111	intermediate filament cytoskeleton

Protein Structure and Domains

PDB ID

MGI:2384570

InterPro

IPR001650 Helicase, C-terminal
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF00270

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite