InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddx21

Summary

InnateDB Protein

IDBP-157721.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddx21

Protein Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 21

Synonyms

AI255159; AL022742; D10Ertd645e; D10Wsu42e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000042691

InnateDB Gene

IDBG-157719 (Ddx21)

Protein Structure

UniProt Annotation

Function

Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase). Functions as cofactor for JUN-activated transcription (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus.

Disease Associations

Tissue Specificity

Highly expressed in liver and testis. Expressed at lower level in brain, lungs, and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 83 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	83 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003724	RNA helicase activity
GO:0003725	double-stranded RNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0008152	metabolic process
GO:0009615	response to virus
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1860494

InterPro

IPR001650 Helicase, C-terminal
IPR006935 Helicase/UvrB domain
IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
IPR012562 GUCT
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00271
PF04851
PF00270
PF08152

PRINTS

PIRSF

SMART

SM00490
SM00487

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JIK5