InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ddx21

Summary

InnateDB Gene

IDBG-157719.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddx21

Gene Name

DEAD (Asp-Glu-Ala-Asp) box polypeptide 21

Synonyms

AI255159; AL022742; D10Ertd645e; D10Wsu42e

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020075

Encoded Proteins

IDBP-157721

DEAD (Asp-Glu-Ala-Asp) box polypeptide 21

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21703541

Ddx21 is a component of a cytosolic viral sensor and is recruited to a complex consisting of Ddx1, Dhx36 and Ticam1, which triggers type I interferon and cytokine response to dsRNA.

InnateDB Annotation from Orthologs

Summary

PMID 21703541

[Homo sapiens] DDX21 is a component of a cytosolic viral sensor and is recruited to a complex consisting of DDX1, DHX36 and TICAM1, which triggers type I interferon and cytokine response to dsRNA. (Demonstrated in murine model)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000165732:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an antigen recognized by autoimmune antibodies from a patient with watermelon stomach disease. This protein unwinds double-stranded RNA, folds single-stranded RNA, and may play important roles in ribosomal RNA biogenesis, RNA editing, RNA transport, and general transcription. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:62580248-62602298

Strand

Reverse strand

Band

Transcripts

ENSMUST00000045866

ENSMUSP00000042691

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 83 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	83 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003724	RNA helicase activity
GO:0003725	double-stranded RNA binding
GO:0004386	helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016787	hydrolase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0008152	metabolic process
GO:0009615	response to virus
GO:0043330	response to exogenous dsRNA
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0016020	membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000165732

View Gene Order

ENSBTAG00000014558

Not yet available

Cross-References

SwissProt

Q9JIK5

TrEMBL

Q8K2L4 Q9CSR3

UniProt Splice Variant

Entrez Gene

56200

UniGene

Mm.413275

RefSeq

NM_019553

OMIM

CCDS

CCDS23891

HPRD

IMGT

MGI ID

MGI:1860494

MGI Symbol

Ddx21

EMBL

AF159131 AF220365 AK012125 AK160095 BC030895 BC043655 CH466553

GenPept

AAD43959 AAF61690 AAH30895 AAH43655 BAB28047 BAE35625 EDL32086

RNA Seq Atlas

56200