InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rtn4

Summary

InnateDB Protein

IDBP-157817.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rtn4

Protein Name

reticulon 4

Synonyms

1110020G17Rik; AA407876; AA409940; AA960376; ASY; C130026I10Rik; mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C; NSP-CL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099907

InnateDB Gene

IDBG-157815 (Rtn4)

Protein Structure

UniProt Annotation

Function

Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. May inhibit BACE1 activity and amyloid precursor protein processing. {ECO:0000269PubMed:20093372, ECO:0000269PubMed:20573699}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001525	angiogenesis
GO:0007399	nervous system development
GO:0007413	axonal fasciculation
GO:0021801	cerebral cortex radial glia guided migration
GO:0030308	negative regulation of cell growth
GO:0030334	regulation of cell migration
GO:0030517	negative regulation of axon extension
GO:0051960	regulation of nervous system development
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0071786	endoplasmic reticulum tubular network organization
GO:2000172	regulation of branching morphogenesis of a nerve

Cellular Component

GO:0005622	intracellular
GO:0005635	nuclear envelope
GO:0005783	endoplasmic reticulum
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0042995	cell projection
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome