InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rtn4

Summary

InnateDB Gene

IDBG-157815.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rtn4

Gene Name

reticulon 4

Synonyms

1110020G17Rik; AA407876; AA409940; AA960376; ASY; C130026I10Rik; mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C; NSP-CL

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020458

Encoded Proteins

IDBP-157817

reticulon 4

IDBP-157819

reticulon 4

IDBP-157821

reticulon 4

IDBP-157825

reticulon 4

IDBP-157827

reticulon 4

IDBP-627773

reticulon 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115310:
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:29692947-29744331

Strand

Forward strand

Band

A3.3

Transcripts

ENSMUST00000102843	ENSMUSP00000099907
ENSMUST00000102842	ENSMUSP00000099906
ENSMUST00000078830	ENSMUSP00000077875
ENSMUST00000102841	ENSMUSP00000099905
ENSMUST00000060992	ENSMUSP00000053754
ENSMUST00000156217
ENSMUST00000141719
ENSMUST00000125735
ENSMUST00000126162
ENSMUST00000170731	ENSMUSP00000126413

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	48 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001525	angiogenesis
GO:0007399	nervous system development
GO:0007413	axonal fasciculation
GO:0021801	cerebral cortex radial glia guided migration
GO:0030308	negative regulation of cell growth
GO:0030334	regulation of cell migration
GO:0030517	negative regulation of axon extension
GO:0051960	regulation of nervous system development
GO:0060317	cardiac epithelial to mesenchymal transition
GO:0071786	endoplasmic reticulum tubular network organization
GO:2000172	regulation of branching morphogenesis of a nerve

Cellular Component

GO:0005622	intracellular
GO:0005635	nuclear envelope
GO:0005783	endoplasmic reticulum
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane
GO:0042995	cell projection
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome