InnateDB Protein
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IDBP-157825.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rtn4
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Protein Name
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reticulon 4
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Synonyms
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1110020G17Rik; AA407876; AA409940; AA960376; ASY; C130026I10Rik; mKIAA0886; mKIAA4153; NgA; NOGO; Nogo-A; Nogo-B; Nogo-C; NSP-CL;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000099905
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InnateDB Gene
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IDBG-157815 (Rtn4)
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Protein Structure
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Function |
Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Involved in down-regulation of growth, stabilization of wiring and restriction of plasticity in the adult CNS. Regulates the radial migration of cortical neurons via an RTN4R-LINGO1 containing receptor complex. May inhibit BACE1 activity and amyloid precursor protein processing. {ECO:0000269PubMed:20093372, ECO:0000269PubMed:20573699}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Anchored to the membrane of the endoplasmic reticulum through 2 putative transmembrane domains. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 48 interaction(s) predicted by orthology.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
48 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1915835
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InterPro |
IPR003388
Reticulon
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PFAM |
PF02453
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q99P72
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PhosphoSite |
PhosphoSite-Q99P72
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
68585
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UniGene |
Mm.488364
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RefSeq |
NP_918940
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MGI ID |
2KO2
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MGI Symbol |
Rtn4
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OMIM |
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CCDS |
CCDS24502
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HPRD |
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IMGT |
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EMBL |
AB073672
AF326337
AK003859
AK220511
AL929371
AY102280
AY102284
AY102286
AY114152
BC032192
BC056373
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GenPept |
AAH32192
AAK08076
AAM73502
AAM73506
AAM73507
AAM73511
AAM77068
BAC75974
BAD90301
CAI24273
CAI24274
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