InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ubqln1

Summary

InnateDB Protein

IDBP-157925.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ubqln1

Protein Name

ubiquilin 1

Synonyms

1110046H03Rik; 1810030E05Rik; AU019746; C77538; D13Ertd372e; Da41; Dsk2; Plic-1; Plic1; Xdrp1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050191

InnateDB Gene

IDBG-157923 (Ubqln1)

Protein Structure

UniProt Annotation

Function

Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors. Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:10549293}. Note=Detected in cytosolic puncta that may correspond to autophagosomes. Detected in neuronal processes and at synapses (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in heart, brain, liver, smooth muscle and kidney. {ECO:0000269PubMed:10549293}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 107 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	107 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0005102	receptor binding
GO:0005488	binding
GO:0005515	protein binding
GO:0019215	intermediate filament binding
GO:0019900	kinase binding
GO:0019904	protein domain specific binding

Biological Process

GO:0006289	nucleotide-excision repair
GO:0031396	regulation of protein ubiquitination
GO:0034976	response to endoplasmic reticulum stress
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087	innate immune response (InnateDB)
GO:0071456	cellular response to hypoxia
GO:0097194	execution phase of apoptosis
GO:1902175	regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0000502	proteasome complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1860276

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR000626 Ubiquitin-like
IPR006636 Heat shock chaperonin-binding
IPR009060 UBA-like
IPR015360 XPC-binding domain
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR016024 Armadillo-type fold
IPR022617 Rad60/SUMO-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00627
PF00240
PF14560
PF09280
PF11976

PRINTS

PIRSF

SMART

SM00213
SM00727
SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8R317