Version 5.4
Mus musculus Gene: Ubqln1
Summary
InnateDB Gene IDBG-157923.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ubqln1
Gene Name ubiquilin 1
Synonyms 1110046H03Rik; 1810030E05Rik; AU019746; C77538; D13Ertd372e; Da41; Dsk2; Plic-1; Plic1; Xdrp1
Species Mus musculus
Ensembl Gene ENSMUSG00000005312
Encoded Proteins
IDBP-157925
ubiquilin 1
IDBP-157927
ubiquilin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21695056
Ubqln1 strongly suppresses the transcriptional activation of Ifnb promoter and is an inhibitor of the Tlr3/Ticam1 anti-viral pathway by reducing Ticam1 protein levels. (Demonstrated in human)
InnateDB Annotation from Orthologs
Summary
PMID 21695056
[Homo sapiens] UBQLN1 strongly suppresses the transcriptional activation of the IFNB promoter and is an inhibitor of the TLR3/TICAM1 anti-viral pathway by reducing TICAM1 protein levels.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000135018:
This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:58176156-58215653
Strand Reverse strand
Band B1
Transcripts
ENSMUST00000058735 ENSMUSP00000050191
ENSMUST00000076454 ENSMUSP00000075782
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 107 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 107 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003684 damaged DNA binding
GO:0005102 receptor binding
GO:0005488 binding
GO:0005515 protein binding
GO:0019215 intermediate filament binding
GO:0019900 kinase binding
GO:0019904 protein domain specific binding
Biological Process
GO:0006289 nucleotide-excision repair
GO:0031396 regulation of protein ubiquitination
GO:0034976 response to endoplasmic reticulum stress
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045087 innate immune response (InnateDB)
GO:0071456 cellular response to hypoxia
GO:0097194 execution phase of apoptosis
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Cellular Component
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000135018
View Gene Order
ENSBTAG00000014827
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
cxcr4_pathway
CXCR4-mediated signaling events
Cross-References
SwissProt Q8R317
TrEMBL Q3V2J6
UniProt Splice Variant
Entrez Gene 56085
UniGene Mm.182053 Mm.403521
RefSeq NM_026842 NM_152234
OMIM
CCDS CCDS26569 CCDS49281
HPRD
IMGT
MGI ID MGI:1860276
MGI Symbol Ubqln1
EMBL AF177345 AK004183 AK048534 AK049298 AK131766 BC010213 BC026847 BC027375 BC028857 BC051098
GenPept AAF01365 AAH10213 AAH26847 AAH27375 AAH28857 AAH51098 BAB23211 BAC33365 BAC33666 BAE20801
RNA Seq Atlas 56085

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca