InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spnb2

Summary

InnateDB Protein

IDBP-158175.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spnb2

Protein Name

spectrin beta 2

Synonyms

9930031C03Rik; AL033301; elf1; elf3; mKIAA4049; Spnb-2; Spnb2; SPTB2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006629

InnateDB Gene

IDBG-158171 (Spnb2)

Protein Structure

UniProt Annotation

Function

Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:9927192}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269PubMed:9927192}. Note=Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes.Isoform 2: Cell membrane; Peripheral membrane protein; Cytoplasmic side.

Disease Associations

Tissue Specificity

Isoform 2 is present in brain, heart, kidney and liver (at protein level). {ECO:0000269PubMed:15262991, ECO:0000269PubMed:9927192}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	26 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	84 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005543	phospholipid binding
GO:0030506	ankyrin binding
GO:0032403	protein complex binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0007182	common-partner SMAD protein phosphorylation
GO:0007184	SMAD protein import into nucleus
GO:0043001	Golgi to plasma membrane protein transport
GO:0051693	actin filament capping
GO:0071709	membrane assembly
GO:0072661	protein targeting to plasma membrane

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005886	plasma membrane
GO:0008091	spectrin
GO:0016020	membrane
GO:0030673	axolemma
GO:0030863	cortical cytoskeleton
GO:0031430	M band
GO:0032437	cuticular plate
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:98388

InterPro

IPR001605 Pleckstrin homology domain, spectrin-type
IPR001715 Calponin homology domain
IPR001849 Pleckstrin homology domain
IPR002017 Spectrin repeat
IPR016343 Spectrin, beta subunit
IPR018159 Spectrin/alpha-actinin
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM

PF00307
PF00169
PF00435
PF11971

PRINTS

PR00683

PIRSF

PIRSF002297

SMART

SM00033
SM00233
SM00150

TIGRFAMs

Post-translational Modifications

Modification

Cross-References