InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Spnb2

Summary

InnateDB Gene

IDBG-158171.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spnb2

Gene Name

spectrin beta 2

Synonyms

9930031C03Rik; AL033301; elf1; elf3; mKIAA4049; Spnb-2; Spnb2; SPTB2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000020315

Encoded Proteins

IDBP-158173

spectrin beta 2

IDBP-158175

spectrin beta 2

IDBP-158177

spectrin beta 2

IDBP-539186

spectrin beta 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115306:
Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein contains an N-terminal actin-binding domain, and 17 spectrin repeats which are involved in dimer formation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:30099395-30268175

Strand

Reverse strand

Band

A3.3

Transcripts

ENSMUST00000011877	ENSMUSP00000011877
ENSMUST00000006629	ENSMUSP00000006629
ENSMUST00000102838	ENSMUSP00000099902
ENSMUST00000145315
ENSMUST00000133466
ENSMUST00000127209
ENSMUST00000124231	ENSMUSP00000114841
ENSMUST00000149117

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 84 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	26 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	84 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005200	structural constituent of cytoskeleton
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005543	phospholipid binding
GO:0030506	ankyrin binding
GO:0032403	protein complex binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000281	mitotic cytokinesis
GO:0007009	plasma membrane organization
GO:0007182	common-partner SMAD protein phosphorylation
GO:0007184	SMAD protein import into nucleus
GO:0043001	Golgi to plasma membrane protein transport
GO:0051693	actin filament capping
GO:0071709	membrane assembly
GO:0072661	protein targeting to plasma membrane

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0008091	spectrin
GO:0016020	membrane
GO:0030673	axolemma
GO:0030863	cortical cytoskeleton
GO:0031430	M band
GO:0032437	cuticular plate
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome