InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Suclg1

Summary

InnateDB Protein

IDBP-158209.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Suclg1

Protein Name

succinate-CoA ligase, GDP-forming, alpha subunit

Synonyms

1500000I01Rik; Sucla1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065113

InnateDB Gene

IDBG-158207 (Suclg1)

Protein Structure

UniProt Annotation

Function

Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity (By similarity). {ECO:0000250}.

Subcellular Localization

Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003878	ATP citrate synthase activity
GO:0004775	succinate-CoA ligase (ADP-forming) activity
GO:0004776	succinate-CoA ligase (GDP-forming) activity
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0044822	poly(A) RNA binding
GO:0046982	protein heterodimerization activity
GO:0048037	cofactor binding

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006104	succinyl-CoA metabolic process
GO:0006105	succinate metabolic process
GO:0008152	metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005886	plasma membrane
GO:0043234	protein complex
GO:0045244	succinate-CoA ligase complex (GDP-forming)
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1927234

InterPro

IPR003781 CoA-binding
IPR005810 Succinyl-CoA ligase, alpha subunit
IPR005811 ATP-citrate lyase/succinyl-CoA ligase
IPR016102 Succinyl-CoA synthetase-like

PFAM

PF02629
PF13380
PF00549

PRINTS

PR01798

PIRSF

PIRSF001553

SMART

SM00881

TIGRFAMs

Post-translational Modifications

Modification

Cross-References